11 Scientific Essays

Scientific Reviews & Essays

In-depth, evidence-based reviews on incretin therapies (GLP-1), intermittent fasting, obesity pharmacotherapy, and clinical metabolism.

Is Sleep Poised to Become a Dietary Risk Factor?

Scientific Review

2026-10-22 8 min

Is Sleep Poised to Become a Dietary Risk Factor?

Can inadequate sleep be classified as a dietary risk factor? Analyzing clinical trials on ghrelin, leptin, ultra-processed cravings, and fat loss.

#Sleep #Appetite Regulation #Metabolism

Read Article Dr. Caner ÖZYILDIRIM

Fasting While Having Insulin Resistance May Not Be Such a Good Idea

Scientific Review

2026-10-20 8 min

Fasting While Having Insulin Resistance May Not Be Such a Good Idea

Why fasting with insulin resistance may not yield expected fat loss. Exploring chronic hyperinsulinemia, muscle catabolism, and circadian feeding.

#Intermittent Fasting #Insulin Resistance #Metabolism

Read Article Dr. Caner ÖZYILDIRIM

Intermittent Fasting Isn't Working for You? Your Gut Microbiome Might Be the Reason

Scientific Review

2026-10-08 8 min

Intermittent Fasting Isn't Working for You? Your Gut Microbiome Might Be the Reason

Strict intermittent fasting not yielding results? Emerging research shows gut microbiome composition and Akkermansia levels dictate metabolic response.

#Intermittent Fasting #Gut Microbiota #Metabolism

Read Article Dr. Caner ÖZYILDIRIM

Your Diet May Be Epigenetically Programming Your Liver for Cancer Years in Advance

Scientific Review

2026-10-06 10 min

Your Diet May Be Epigenetically Programming Your Liver for Cancer Years in Advance

Years of high-fat nutrition can epigenetically reprogram liver cells long before tumors appear. Discover how diet alters chromatin and cancer risk.

#Liver Health #MASLD #Epigenetics

Read Article Dr. Caner ÖZYILDIRIM

Can Nutrients Naturally Stimulate GLP-1? The Science of Dietary Incretin Secretion

Scientific Review

2026-10-01 11 min

Can Nutrients Naturally Stimulate GLP-1? The Science of Dietary Incretin Secretion

Can nutrients naturally stimulate GLP-1? We explore the physiology of dietary fiber, protein, and gut L-cells in triggering natural incretin secretion.

#GLP-1 #Incretins #Nutrition

Read Article Dr. Caner ÖZYILDIRIM

There Is a Subset of Patients Resistant to GLP-1 Therapies: Why Do Some Not Respond?

Clinical Analysis

2026-09-29 11 min

There Is a Subset of Patients Resistant to GLP-1 Therapies: Why Do Some Not Respond?

Why do some patients fail to lose weight on GLP-1 therapies? We examine non-responder phenotypes, genetic polymorphisms, and resistance mechanisms.

#GLP-1 #Non-responders #Pharmacogenomics

Read Article Dr. Caner ÖZYILDIRIM

How Does a Blood Sugar-Raising Hormone Promote Weight Loss? The Paradox of Glucagon

Biochemical Deep Dive

2026-09-24 9 min

How Does a Blood Sugar-Raising Hormone Promote Weight Loss? The Paradox of Glucagon

How does glucagon, a blood sugar-raising hormone, induce weight loss? Unpacking the glucagon paradox and next-generation tri-agonists like retatrutide.

#Glucagon #Incretin Tri-agonists #Metabolism

Read Article Dr. Caner ÖZYILDIRIM

The GLP-1 Exit Strategy: What Actually Happens When You Discontinue Incretin Therapy?

Clinical Protocol

2026-09-22 10 min

The GLP-1 Exit Strategy: What Actually Happens When You Discontinue Incretin Therapy?

What happens when you discontinue GLP-1 incretin therapy? Evidence on metabolic adaptation, weight regain, and clinical maintenance exit strategies.

#GLP-1 Discontinuation #Weight Maintenance #Metabolic Adaptation

Read Article Dr. Caner ÖZYILDIRIM

The Muscle Mass Panic with GLP-1: Are We Losing Muscle or Shrinking Overall Body Mass?

Body Composition Analysis

2026-09-17 9 min

The Muscle Mass Panic with GLP-1: Are We Losing Muscle or Shrinking Overall Body Mass?

Is muscle loss on GLP-1 agonists cause for panic? Reviewing DEXA body composition data, lean mass ratios, and dietary protein intake strategies.

#Sarcopenia #Muscle Mass #DEXA

Read Article Dr. Caner ÖZYILDIRIM

GLP-1 Agonists: Is Weight Loss the Same as Truly Treating the Disease of Obesity?

Philosophical & Medical Analysis

2026-09-15 10 min

GLP-1 Agonists: Is Weight Loss the Same as Truly Treating the Disease of Obesity?

Do GLP-1 receptor agonists truly treat obesity as a chronic disease or just reduce body mass? A critical review of EASO guidelines and adipose health.

#Obesity Medicine #EASO Guidelines #Pathophysiology

Read Article Dr. Caner ÖZYILDIRIM

Feeling Full on GLP-1 Doesn't Change the Fact That Your Cells Might Be Starving

Clinical Nutrition

2026-09-09 8 min

Feeling Full on GLP-1 Doesn't Change the Fact That Your Cells Might Be Starving

Suppressed appetite on GLP-1 does not mean your cells are nourished. Learn why hidden malnutrition and micronutrient deficiencies emerge during therapy.

#Nutritional Deficiencies #Malnutrition #GLP-1

Read Article Dr. Caner ÖZYILDIRIM

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